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FOR NEWLY DIAGNOSED PATIENTS

Are your CML patients getting the response you anticipated with their initial TKI?

Most newly diagnosed patients don’t reach MMR within the 1st year of treatment^1-3

Graphic showing that for newly diagnosed patients up to 73% (1G TKI) and up to 54% (2G TKI) did not achieve MMR by 12 months.

Some patients discontinued their 1st TKI due to adverse reactions^3-5:

Graphic showing that up to 14% of patients discontinued their 1st TKI due to adverse reactions in their first year.

Patients with CML need the efficacy of a TKI to manage their disease, but Ars can make navigating treatment challenging for some.

NCCN Guidelines

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) recognize MMR at Year 1 as an important milestone for patients with CML⁶

What could this milestone mean to your newly diagnosed patients

PATIENT PROFILES

What initial TKI considerations could help give your patients with Ph+ CML-CP a strong start?

To date, only one trial has studied all current standard-of-care TKI options for newly diagnosed adult patients.

2G, 2nd generation; AR, adverse reaction; CML, chronic myeloid leukemia; DMR, deep molecular response; MMR major molecular response; NCCN, National Comprehensive Cancer Network; Ph+ CML-CP, Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase; TKI, tyrosine kinase inhibitor.

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References: 1. Hochhaus A, Saglio G, Hughes TP, et al. Leukemia. 2016;30(5):1044-1054. 2. Cortes JE, Saglio G, Kantarjian HM, et al. J Clin Oncol. 2016;34(20):2333-2340. 3. Brümmendorf TH, Cortes JE, Milojkovic D, et al. Leukemia. 2022;36(7):1825-1833. 4. Saglio G, Kim D-W, Issaragrisil S, et al. N Engl J Med. 2010;362(24)(suppl):1-15. 5. Kantarjian H, Shah NP, Hochhaus A, et al. N Engl J Med. 2010;362(24):2260-2270. 6. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) for Chronic Myeloid Leukemia V.1.2026. ©National Comprehensive Cancer Network, Inc. 2025. All rights reserved. Accessed April 21, 2026. To view the most recent and complete version of the guidelines, go to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 7. Scemblix. Prescribing information. Novartis Pharmaceuticals Corp.

Are your CML patients getting the response you anticipated with their initial TKI?

NCCN Guidelines

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) recognize MMR at Year 1 as an important milestone for patients with CML⁶

What initial TKI considerations could help give your patients with Ph+ CML-CP a strong start?

Important Safety Information

Indications

Are your CML patients getting the response you anticipated with their initial TKI?

NCCN Guidelines

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) recognize MMR at Year 1 as an important milestone for patients with CML6

What initial TKI considerations could help give your patients with Ph+ CML-CP a strong start?

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) recognize MMR at Year 1 as an important milestone for patients with CML⁶